Medical Acupuncture: Mechanisms, Evidence, and Clinical Translation—From Biomolecular Signaling to Neuroimmune and Endocrine Regulation offers a contemporary exploration of acupuncture through the lens of modern biomedical science. Moving beyond traditional descriptions, the book traces how a simple needle stimulus can initiate a cascade of events that extends from local tissue interactions to the nervous, immune, and endocrine systems. Readers are guided through the anatomical and physiological foundations of acupuncture, revealing how specific points interact with connective tissue, sensory pathways, autonomic networks, and whole-body regulatory processes. Clear conceptual models bring together diverse strands of evidence into a coherent account of how acupuncture may influence health and disease. Building on this foundation, the book examines how these biological processes translate into clinical practice across a range of conditions, including cancer survivorship, wound healing, developmental disorders, aging, chronic kidney disease–associated pruritus, and other complex health challenges. It also explores the logic of point combinations, the opportunities and limitations of current knowledge, and the emerging technologies that are reshaping the field. Designed for clinicians, researchers, educators, and advanced students, this volume provides a rigorous yet accessible framework for understanding acupuncture as a system-level therapeutic intervention situated at the intersection of biology, medicine, and clinical care.