The Covid-19 is a viral disease that affects public health and huge economic crises around the world. Some reviews studies identified the importance of nutrients and polyphenols to combat severe acute respiratory syndrome (SARS) coronavirus (CoV) infection via reducing inflammation and oxidative stress. For example: vitamin C, vitamin E, carotenoids and polyphenols can interact with transcription factors, associated to anti-inflammatory and antioxidant effects and polyphenols has potential ability to against SARS-CoV-2 infection through the resulting host inflammation, oxidative stress and signaling pathways.